Fig. 5: Exo-STIM1-KO miR-145 inhibits angiogenesis through targeting IRS1 signal pathway in human umbilical vein endothelial cells (HUVECs). | Cell Death & Disease

Fig. 5: Exo-STIM1-KO miR-145 inhibits angiogenesis through targeting IRS1 signal pathway in human umbilical vein endothelial cells (HUVECs).

From: STIM1 promotes angiogenesis by reducing exosomal miR-145 in breast cancer MDA-MB-231 cells

Fig. 5

A Western blot analysis of IRS1 and its downstream signal proteins in HUVECs. B Quantification of the results in (A). C Schematic diagrams of miR-145 binding sites in the 3’-UTR of IRS1. D The levels of miR-145 in HUVECs after various treatments. E Images of tube formation of HUVECs after various treatments. F Quantification of the results in (E). G Representative migration of HUVECs after various treatments. H Quantification of the results in (G). I Western blot analysis of IRS1 and the downstream signal proteins in HUVECs treated with Exo-STIM1-KO plus/or miR-145 antagomir. J Quantification of the results in (I). Data represent mean ± SEM from three independent experiments (n = 3). *P < 0.05, **P < 0.01, and ***P < 0.001.

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