Fig. 3: ZNF280A knockdown inhibited LUAD development in vivo.
From: ZNF280A promotes lung adenocarcinoma development by regulating the expression of EIF3C
A 22 days post injection of NCI-H1299 cells with or without ZNF280A knockdown, the volume of tumors formed in mice was measured and calculated at indicated time intervals. B In vivo imaging was performed to evaluate the tumor burden in mice of shZNF280A and shCtrl groups at day 34 post tumor inoculation. C The bioluminescence intensity was scanned and used as a representation of tumor burden in mice of shZNF280A and shCtrl groups. D, E Mice were killed at day 34 post injection, and the tumors were removed for collecting photos D and weighing E. F The expression of Ki67 in sections of xenografts was detected by IHC analysis (Scale bar = 50 μm). Data were shown as mean ± SD. *P < 0.05, **P < 0.01, ***P < 0.001.
