Fig. 4: DANCR modulated MALAT1 expression by enhancing the RNA stability of MALAT1. | Cell Death & Disease

Fig. 4: DANCR modulated MALAT1 expression by enhancing the RNA stability of MALAT1.

From: LncRNA DANCR represses Doxorubicin-induced apoptosis through stabilizing MALAT1 expression in colorectal cancer cells

Fig. 4: DANCR modulated MALAT1 expression by enhancing the RNA stability of MALAT1.

A Differentially expressed genes upon DANCR knockdown in HCT116 cells are shown in volcano plots. X axis: Log2 [fold change (shRNA vs. Control)]; Y axis: −Log10 (p value). B Decreased expression of MALAT1 upon DANCR knockdown was validated by qRT-PCR in HCT116, SW620, and HT-29 cells. *p < 0.05. C Decreased expression of MALAT1 upon DANCR knockdown was validated using qRT-PCR in xenograft tumor tissues (n = 7 for each group). *p < 0.05. D The expression levels of MALAT1 (left) and PTEN (right) upon DANCR knockdown in HCT116 and SW620 cells were detected by qRT-PCR at 0, 3, 6, 9, and 12 h post-treatment with Actinomycin D. *p < 0.05.

Back to article page