Fig. 1: Schematic and atomistic representation of Fol-miR21-NC.

A Schematic top view of the four sequestering units in the unbound state. B Schematic top view highlighting the bound state of Fol-NC upon interaction with miR-21 molecules. C, D Three-dimensional representation of the two states, showing the conformational change occurring in the Fol-miR21-NC after binding to miR-21.