Fig. 2: The expression of STING is increased in IL-1β-triggered chondrocytes. | Cell Death & Disease

Fig. 2: The expression of STING is increased in IL-1β-triggered chondrocytes.

From: STING promotes senescence, apoptosis, and extracellular matrix degradation in osteoarthritis via the NF-κB signaling pathway

Fig. 2: The expression of STING is increased in IL-1β-triggered chondrocytes.

The protein expression of γh2ax, cGAS, STING in chondrocytes were explored by western blot and its quantification was detected by ImageJ. A–B The impact of different concentrations of treatment with IL-1β on mouse chondrocytes. The chondrocytes were exposed to 0, 10, 20, 30, 40 (ng/ml) IL-1β for 24 h. C–D The impact of different durations of treatment with IL-1β on mouse chondrocytes. The chondrocytes were incubated with IL-1β (10 ng/ml) for 0, 6, 12, 24 h. E Representative immunofluorescence staining of γh2ax in IL-1β (10 ng/ml, 24 h) induced chondrocytes (bar:10μm). All data were indicated as the mean ± SD (n = 5); *P < 0.05, **P < 0.01.

Back to article page