Fig. 1: T-DM1 showed antitumor effects in vitro by being internalized into HER2-positive GC cells. | Cell Death & Disease

Fig. 1: T-DM1 showed antitumor effects in vitro by being internalized into HER2-positive GC cells.

From: Targeting the autophagy promoted antitumor effect of T-DM1 on HER2-positive gastric cancer

Fig. 1: T-DM1 showed antitumor effects in vitro by being internalized into HER2-positive GC cells.

A NCI-N87 cells were intreated with incremental concentrations of T-DM1 for 72 h and assessed with CCK-8. The results are expressed as the mean ± S.D. (***P < 0.001, n = 3). B The protein expression level of HER was measured by immunoblot analysis in NCI-N87, MDA-MB-231 (HER2-negative BC), and SK-BR-3 cells (HER2-positive BC). C Confocal microscopy experiments showed the whole process of fluorescently labeled T-DM1 internalization in NCI-N87 cells. T-DM1 was labeled with the Alexa Fluor™ 647 Microscale Protein Labeling Kit.

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