Fig. 2: Ferric iron deposition in the globus pallidus. | Cell Death & Disease

Fig. 2: Ferric iron deposition in the globus pallidus.

From: Intranasal administration of α-synuclein preformed fibrils triggers microglial iron deposition in the substantia nigra of Macaca fascicularis

Fig. 2

A–D Chemical staining of iron ions showed a gradual increase in iron deposition, 1 (B), 4 (C), and 17 months (D) after the α-syn PFFs treatment, compared to the control (A) in the ipsilateral side. E–H Chemical staining of iron ions in the control (E) and 1 (F), 4 (G), and 17 months (H) after the treatment with α-syn PFFs in the contralateral side. The inset images depict the enlarged small boxes in A–H. I–K Quantitative analyses of the iron deposition density in the globus pallidus (ipsilateral side: I; contralateral side: J; both sides: K). α-Syn, α-synuclein. The data are presented as the mean ± SEM of three independent experiments. **p < 0.01 vs. control group, ##p < 0.01 vs. 1-month group, ΔΔp < 0.01 vs. 4-month group, one-way ANOVA (I, J). Scale bars: 50 μm in A–H and 50 µm in the insets.

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