Fig. 2: Fibrosis inhibits necroptosis signaling triggered by D-GalN/LPS, which can be attributed to M2-like macrophages. | Cell Death & Disease

Fig. 2: Fibrosis inhibits necroptosis signaling triggered by D-GalN/LPS, which can be attributed to M2-like macrophages.

From: M2-like macrophages exert hepatoprotection in acute-on-chronic liver failure through inhibiting necroptosis-S100A9-necroinflammation axis

Fig. 2

a The expression of necroptosis markers including RIPK3, MLKL, and P-MLKL in control and fibrotic mice with or without D-GalN/LPS challenge. b The mRNA levels of necroptosis marker MLKL in control and fibrotic mice with or without D-GalN/LPS challenge. (n = 5–7). c Comparison of the expression of necroptosis markers including RIPK3, MLKL, and P-MLKL in fibrotic mice upon acute insult with or without M2-like macrophage depletion (Clo: Liposome-encapsulated clodronate). d Comparison of the expression of necroptosis markers including RIPK3, MLKL, and P-MLKL in control mice upon acute insult with or without M2-like macrophage transfer. GL D-GalN/LPS.

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