Fig. 5: M2-like macrophages in the fibroic liver inhibit necroptosis- and S100A9-dependent NLRP3 inflammasome activation and ensuing necroinflammation. | Cell Death & Disease

Fig. 5: M2-like macrophages in the fibroic liver inhibit necroptosis- and S100A9-dependent NLRP3 inflammasome activation and ensuing necroinflammation.

From: M2-like macrophages exert hepatoprotection in acute-on-chronic liver failure through inhibiting necroptosis-S100A9-necroinflammation axis

Fig. 5

Comparison of NLRP3 expression in control, acutely injured, and fibrotic mice by immunofluorescence (a) and western blot (b) analysis. The expression of NLRP3 in mice receiving RIPK3 or MLKL inhibitor (c) and S100A9 inhibitor (d) followed by acute insult. e The expression of necroinflammation markers ASC and cleaved Caspase-1 in acutely injured mice and fibrotic mice with or without acute insult. f The expression of proinflammatory cytokine IL-1β in control and fibrotic mice with or without acute insult (n = 5–9). g Comparison of the expression of NLRP3 (upper), ASC (middle), and cleaved caspase-1 (lower) in acutely injured mice with or without M2-like macrophage transfer. h Comparison of the expression of NLRP3 (upper), ASC (middle), and cleaved caspase-1 (lower) in fibrotic mice upon acute insult with or without M2-like macrophage depletion.

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