Fig. 7: ADT-OH inhibits melanoma xenograft growth in vivo but has little effect on FADD knockout melanoma. | Cell Death & Disease

Fig. 7: ADT-OH inhibits melanoma xenograft growth in vivo but has little effect on FADD knockout melanoma.

From: ADT-OH, a hydrogen sulfide-releasing donor, induces apoptosis and inhibits the development of melanoma in vivo by upregulating FADD

Fig. 7: ADT-OH inhibits melanoma xenograft growth in vivo but has little effect on FADD knockout melanoma.The alternative text for this image may have been generated using AI.

a Representative therapeutic efficacy of ADT-OH for B16F10 nc and B16F10 FADD KO melanoma therapy. b Tumour growth curves. B16F10 nc and B16F10 FADD KO tumour mice per group (n = 8 mice) were gavage with vehicle, ADT-OH. Tumour volumes among different groups were compared. Data are presented as mean ± SEM. **P < 0.01. c H&E staining of the tumour sections. The representative images (100×) showed necrotic areas of B16F10 nc and B16F10 FADD KO tumour tissue treated with vehicle and ADT-OH; N necrotic tumour regions, V vital tumour regions. d Western blots for FADD expression by B16F10 FADD KO vs B16F10 nc tumour tissues after vehicle and ADT-OH (37.5 mg/kg) treatment. Data are presented as mean ± SD. ***P < 0.001.

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