Fig. 4: Patient 2 presented with severe persistent scalp erosion and altered KCs differentiation reverted by PRIMA-1MET treatment.
From: Improvement of epidermal covering on AEC patients with severe skin erosions by PRIMA-1MET/APR-246
a Patient 2 displays skin erosion of the scalp. b Altered patient 2 KCs differentiation was rescued by PRIMA-1MET as illustrated by immunostaining analyses; scale bar: 100 μm. c Formulated PRIMA-1MET was applied daily on the whole surface of the scalp of patient 2. First improvement was seen during the first 5 weeks of treatment. First epidermalization areas were seen at week 4 (not shown). Confluence of such areas was seen at week 17 (yellow arrows). Remarkably, the whole peripheric scalp was completely re-epidermized (back arrows). Most of the scalp became covered by week 32. KC keratinocytes, KRT keratin, ZNF750 zinc finger protein 750.
