Fig. 1: TKT deficiency reduced bile acids in livers. | Cell Death & Disease

Fig. 1: TKT deficiency reduced bile acids in livers.

From: The nuclear translocation of transketolase inhibits the farnesoid receptor expression by promoting the binding of HDAC3 to FXR promoter in hepatocellular carcinoma cell lines

Fig. 1

a Metabolomic analysis of bile acids in livers from mice at 2 months of age. b Mass spectrometric detection of bile acids at 6 months of age in livers from mice following DEN/HFD treatment. c Mass spectrometric detection of bile acids at 6 months of age in serum from mice following DEN/HFD treatment. d QPCR analysis of TKT, FXR, and BSEP mRNA expression in TKT+/+Alb-cre and TKTfl/flAlb-Cre mice livers. Data are presented as mean ± squared error (SEM), the bar indicates the mean. Statistical significance was calculated using two-tailed unpaired t-test, *p < 0.05, **p < 0.01.

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