Fig. 2: The expression of FXR is negatively controlled by TKT. | Cell Death & Disease

Fig. 2: The expression of FXR is negatively controlled by TKT.

From: The nuclear translocation of transketolase inhibits the farnesoid receptor expression by promoting the binding of HDAC3 to FXR promoter in hepatocellular carcinoma cell lines

Fig. 2

a, b Western blot analysis shows that TKT negatively regulates FXR expression in L-O2 cells. c, d Western blot analysis shows that TKT negatively regulates FXR expression in SMMC-7721 cells. e, f Western blot analysis shows that TKT negatively regulates FXR expression in HepG2 cells. g, h QPCR analysis shows that TKT negatively regulates FXR mRNA level in SMMC-7721 cells. Data are presented as mean ± squared error (SEM), the bar indicates the mean. Statistical significance was calculated using two-tailed unpaired t-test, *p < 0.05, **p < 0.01, ***p < 0.001.

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