Fig. 5: miR-762 promotes progression of UCB via targeting △NP63. | Cell Death & Disease

Fig. 5: miR-762 promotes progression of UCB via targeting △NP63.

From: Circular RNA FAM114A2 suppresses progression of bladder cancer via regulating ∆NP63 by sponging miR-762

Fig. 5

a Targetscan prediction results shown that TP63 3′UTR contain complementary sequence of miR-762. b Luciferase reporter assay was performed to confirm the relationship between miR-762 and TP63/△NP63. c, d the expression level of △NP63 was detected by western blot in 5637 and T24 cells, which were transfected with miR-762 mimic and inhibitor. e–g △NP63 was at significantly lower level in high-grade UCB tissues, while not notably decreased in low grade UCB tissues, compared with noncancerous tissues. Date are mean ± SEM, n = 3. ***p < 0.001, **p < 0.01, *p < 0.05 (student’s t test).

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