Fig. 1: lncRNA FOXD2-AS1 were upregulated in LSCC patients with chemotherapy resistance and its high expression level was correlated with patients’ poor prognostics. | Cell Death & Disease

Fig. 1: lncRNA FOXD2-AS1 were upregulated in LSCC patients with chemotherapy resistance and its high expression level was correlated with patients’ poor prognostics.

From: Long noncoding RNA FOXD2-AS1 enhances chemotherapeutic resistance of laryngeal squamous cell carcinoma via STAT3 activation

Fig. 1: lncRNA FOXD2-AS1 were upregulated in LSCC patients with chemotherapy resistance and its high expression level was correlated with patients’ poor prognostics.The alternative text for this image may have been generated using AI.

a FOXD2-AS1 mRNA expression in primary head and neck squamous cell carcinoma (HNSC) tissues (tumor) and matched normal tissues (normal) from UALCAN webserver. b, c FOXD2-AS1 mRNA expression in primary HNSC tissues from patients with different clinical stages and tumor grades from UALCAN webserver, respectively. d–f Prognostic value of FOXD2-AS1 expression in HNSC patients by using online Kaplan–Meier Plotter analysis. d Overall survival (OS) of 259 stage IV HNSC patients according the FOXD2-AS1 status. The median value of FOXD2-AS1 expression levels in these 259 tissues was used to stratify the high and low expression levels of FOXD2-AS1. e, f OS of 499 HNSC patients according the FOXD2-AS1 status. The median value and the best cutoff value of FOXD2-AS1 expression levels in these 499 tissues was used to stratify the high and low expression levels of FOXD2-AS1, respectively. g Real-time PCR analysis of FOXD2-AS1 expression in 24 primary laryngeal squamous cancer tissues and matched adjacent normal tissues. h FOXD2-AS1 expression were significantly increased in 21 out of 24 cases of tumor comparing with paired normal tissues. i FOXD2-AS1 mRNA expression in primary HNSC tissues from patients with different clinical stages. j FOXD2-AS1 mRNA expression in primary HNSC tissues from patients with different relapse status. Transcript levels were normalized to GAPDH expression. *P < 0.05, **P < 0.01, and ***P < 0.001.

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