Fig. 6: TGEV-encoded NSP10 and NSP16 mediate cell proliferation and Lgr5 ISCs fate. | Cell Death & Disease

Fig. 6: TGEV-encoded NSP10 and NSP16 mediate cell proliferation and Lgr5 ISCs fate.

From: Transmissible gastroenteritis virus targets Paneth cells to inhibit the self-renewal and differentiation of Lgr5 intestinal stem cells via Notch signaling

Fig. 6

a Cell proliferation (KI67), CD24 cells number and Notch signaling factors DII4 and Hes5 were analyzed in TGEV gene stable cell lines. Venn diagram depicts the numbers of decreased cell proliferation and CD24 cells number and down-regulated Notch signaling identified by using FACS and western blot. b FACS for KI67 in TGEV NSPs stable cell lines. c Notch factor and intestinal epithelium markers Muc2, SI, CgA, and CD24 were tested by western blot in TGEV NSPs stable cell lines. d FACS for CD24 in TGEV NSPs stable cell lines.

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