Fig. 6: P53 regulated mitophagy via the PINK1–Parkin pathway. | Cell Death & Disease

Fig. 6: P53 regulated mitophagy via the PINK1–Parkin pathway.

From: P53 and Parkin co-regulate mitophagy in bone marrow mesenchymal stem cells to promote the repair of early steroid-induced osteonecrosis of the femoral head

Fig. 6

a P53 interacted with Parkin to inhibit Parkin mitochondrial translocation and mitochondrial-membrane protein ubiquitination (n = 3). b Observation of mitophagy by TEM (n = 3). c, d MitoTracker Green analysis of mitochondrial content (n = 3). e, f qPCR analysis of mtDNA (n = 3). In (d–f), data are presented as means ± SD. Statistical significances were calculated by ANOVA. Data were compared with the H2O2− EGFP and H2O2− Parkin groups: *P < 0.05. Data were compared with the H2O2+ EGFP and H2O2+ Parkin groups: #P < 0.05. PINK1 = phosphatase and tensin homolog (PTEN)-induced putative kinase protein 1.

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