Fig. 2: The neuronal AIM2 inflammasome-mediated pyroptosis pathway was explored in the mouse temporal cortex after SAH. | Cell Death & Disease

Fig. 2: The neuronal AIM2 inflammasome-mediated pyroptosis pathway was explored in the mouse temporal cortex after SAH.

From: Inhibition of AIM2 inflammasome activation alleviates GSDMD-induced pyroptosis in early brain injury after subarachnoid haemorrhage

Fig. 2

a Representative Nissl staining images of temporal cortex in sham, post-SAH 24 h and post-SAH 72 h groups; b Representative immunohistochemistry images of AIM2, GSDMD, caspase-1 and ASC in sham, post-SAH 24 h and post-SAH 72 h groups; c Western blot assay for the expression of AIM2, GSDMD, GSDMD-N, caspase-1, caspase-1 p20 and ASC in temporal cortex after SAH; d Quantification of AIM2, GSDMD, GSDMD-N, caspase-1, caspase-1 p20 and ASC. n = 6 per group. Bars represent the mean ± S.E.M. *P < 0.05, **P < 0.01, ***P < 0.001, and ns means non-significant. Scale bars = 50 μm. GSDMD gasdermin D; GSDMD-N N-terminus of gasdermin D; ASC apoptosis-associated speck-like protein containing a CARD.

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