Fig. 3: Light responses are drastically reduced in rd3/rd3 GCAPs−/− mice. | Cell Death & Disease

Fig. 3: Light responses are drastically reduced in rd3/rd3 GCAPs−/− mice.

From: GCAP neuronal calcium sensor proteins mediate photoreceptor cell death in the rd3 mouse model of LCA12 congenital blindness by involving endoplasmic reticulum stress

Fig. 3: Light responses are drastically reduced in rd3/rd3 GCAPs−/− mice.

Electroretinographic recordings from 40-d-old wt, rd3/rd3, GCAPs−/−, and rd3/rd3 GCAPs−/− mice in response to light stimuli of increasing intensity at scotopic or photopic conditions. Representative recordings are shown from one mouse of each genotype, evoked by light pulses of increasing intensity (indicated in cd/s/m2). Scotopic a-wave and b-wave amplitudes (mean ± SD) and photopic b-wave amplitudes are plotted at different light intensities from a total of four wt mice, seven rd3/rd3 mice, five GCAPs−/−, and five rd3/rd3 GCAPs−/− mice. Both GCAPs−/− and rd3/rd3 mice showed substantially reduced responses when compared to wild-type responses. GCAPs ablation in rd3/rd3 mice resulted in nearly abolished responses at the scotopic or photopic range.

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