Fig. 3: Kidney function loss and tissue injury induced by cisplatin were attenuated by paricalcitol pretreatment. | Cell Death & Disease

Fig. 3: Kidney function loss and tissue injury induced by cisplatin were attenuated by paricalcitol pretreatment.

From: VDR activation attenuate cisplatin induced AKI by inhibiting ferroptosis

Fig. 3

A, B Serum BUN and Cr levels of each group at 48 h after indicative treatment were determined. C Histological changes of renal cortex by HE staining at 48 h after indicated treatment, and tissue injury scores in each group were statistically analyzed. Scale bar = 50 μm. D Cell death was assessed by TUNEL staining (green d–f). paricalcitol reduced TUNEL + cells in cisplatin induced AKI kidneys. blue fluorescence (g–i) represent nuclear staining. Representative image and quantification as mean ± SD of five mice per group. Scale bar = 50 μm. *P < 0.05, **P < 0.01, n = 8. Pari stands for VDR agonist paricalcitol.

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