Fig. 6: GPX4 are transcriptionally regulated by transcriptional factor VDR.
From: VDR activation attenuate cisplatin induced AKI by inhibiting ferroptosis
A Predicted VDR binding sites in human and mouse GPX4 gene promoter regions. Human and mouse GPX4 gene upstream regions were analyzed for VDR binding sites by JASPAR online analysis (http://jaspar.genereg.net). The potential binding sites of 90% chance (relative score) to bind VDR are listed. B Luciferase activity assay were conducted to assess the interaction between GPX4 gene promoter regions and transcription factor VDR in human 293 T cells. Luciferase reporter plasmid containing GPX4 promoter sequence (or blank sequence) were transinfected into the control 293 cells or VDR expressed cells, luciferase activity were quantitatively analyzed. The data are presented as the mean ± SD, *P < 0.05, **P < 0.01. n = 3.
