Table 1 Registered clinic trials of HBSP (ClinicalTrial and ICTRP, updated July 2019).
From: Erythropoietin and its derivatives: from tissue protection to immune regulation
Registered no. | Start date | Status | Study contents | Conditions | Study design | Study population | Phase | Locations | Publication |
|---|---|---|---|---|---|---|---|---|---|
EUCTR2010-018584-41-NL | July 2010 | Unknown | ARA290 as therapeutic strategy in no-option critical limb ischemia patients | Critical limb ischemia | Double-blind RCT | n = 8 | 2 | Netherlands | Not available |
EUCTR2010-021518-45-NL | July 2010 | Unknown | Effectiveness of ARA290 in the treatment of pain in neuropathic pain patients | Neuropathic pain | Double-blind RCT | Not available | Not available | Netherlands | Not available |
EUCTR2010-023469-22-NL | March 2011 | Unknown | ARA 290 as therapeutic strategy in rheumatoid arthritis | Rheumatoid arthritis | Non-RCT | n = 12 | 2 | Netherlands | Not available |
EUCTR2010-024364-18-NL | April 2011 | Unknown | Effects of ARA290 on the cognitive and neural processing of emotions in healthy volunteers | Emotional information processing | Double-blind RCT | Not available | Not available | Netherlands | Not available |
NTR3081 | October 2011 | Completed | Effectiveness of ARA290 on pain relief in sarcoidosis patients with small-fiber neuropathy | Sarcoidosis Small fiber neuropathy | Double-blind RCT | n = 24 | Not available | Netherlands | Heij et al. [101] |
NTR3131 | October 2011 | Recruiting | ARA290 and the ventilatory response to hypoxia and pain responses in healthy volunteers | Hypoxia; Hypoxic pulmonary vasoconstriction; Hypoxic ventilatory response | Crossover | n = 16 | Not available | Netherlands | Not available |
NCT02070783 | February 2012 | Completed | Effects of ARA290 on the cognitive and neural processing of emotions in healthy volunteers | Depression | Double-blind RCT | n = 36 | 1 and 2 | Netherlands | Cerit et al. [102] |
NTR3575 | July 2012 | Completed | Effects of ARA 290 on the regrowth of epidermal nerve fibers in patients with sarcoidosis | Sarcoidosis small fiber; Neuropathy pain | Double-blind RCT | n = 40 | Not available | Netherlands | Dahan et al. [103] |
EUCTR2012-003688-24-NL | December 2012 | Unknown | Safety and effects of ARA 290 on pain relief in chronic pain from complex regional pain syndrome type 1 | Complex regional pain syndrome | Double-blind RCT | Not available | Not available | Netherlands | Not available |
NCT01933529 | October 2013 | Unknown | Effects of ARA290 on prediabetes and type 2 diabetes | Type 2 diabetes; Impaired glucose tolerance; Impaired fasting glucose | Double-blind RCT | n = 24 | 2 | Sweden | Not available |
NCT02039687 | January 2014 | Completed | Effects of ARA290 on corneal nerve fiber density and neuropathic symptoms of subjects with sarcoidosis | Neuropathy of Sarcoidosis | Double-blind RCT | n = 64 | 2 | United States; Netherlands | Culver et al. [104] |
