Fig. 6: A20 expression is inversely correlated with PFKL in HCC patients.
From: A20 targets PFKL and glycolysis to inhibit the progression of hepatocellular carcinoma
a A20 expression is inversely with PFKL. Human HCC samples were paired as tumor tissue (designated as T) and adjacent non-tumor tissue (designated as NT). Samples were lysed and directly subjected to western blotting. 10 pairs of samples showcasing an inverse correlation are shown. b Immunohistochemical staining of A20 and PFKL proteins in tumor and adjacent non-tumor tissues. A20 expression was negatively correlated with the PFKL level in human HCC specimens (magnification, left panel, ×100; right panel, ×400). c A20 and PFKL mRNA levels are inversely correlated in non-metastatic tissues and metastatic tissues. Scatterplot data are from clinical data sets from GSE364. d Kaplan–Meier overall survival curves of HCC patients in the Protein Atlas website showing that high expression of PFKL significantly correlates with poor overall survival.
