Fig. 1: Increased CYLD phosphorylation is a frequent event in ATLL cells and is mediated by viral TAX oncoprotein. | Cell Death & Disease

Fig. 1: Increased CYLD phosphorylation is a frequent event in ATLL cells and is mediated by viral TAX oncoprotein.

From: Reversal of CYLD phosphorylation as a novel therapeutic approach for adult T-cell leukemia/lymphoma (ATLL)

Fig. 1

a Lysates from 3T8, HUT78, C1866, and MT4 cells were analyzed by blotting with the indicated antibodies. β-actin was blotted as a loading control. 3T8 is a Jurkat clone used as a negative control. HUT78 is a Sézary Syndrome cell line. C1866 and MT4 are HTLV-1-positive ATLL cell lines. b Lysates from 3T8, SLB1, and MT2 cells were analyzed by blotting with the indicated antibodies. β-actin was blotted as a loading control. 3T8 is a Jurkat clone used as a negative control. SLB1 and MT2 are HLTV-1-positive ATLL cell lines. c HEK293 EBNA cells were transfected with plasmids encoding a control protein or TAX together with that for myc-CYLD. Forty-eight hour post transfection, lysates were blotted for TAX, phospho-CYLD and CYLD.

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