Fig. 2: CYLD phosphorylation is mediated by IKKs and can be reversed by IKK inhibitors. | Cell Death & Disease

Fig. 2: CYLD phosphorylation is mediated by IKKs and can be reversed by IKK inhibitors.

From: Reversal of CYLD phosphorylation as a novel therapeutic approach for adult T-cell leukemia/lymphoma (ATLL)

Fig. 2

a MT4 cells were treated with the indicated concentrations of MRT67307, TPCA, or both inhibitors for 24 h. DMSO was used as a negative control. Lysates were sequentially blotted with the indicated antibodies. b, c MT4 cells were treated as indicated with 5 µM (b) or 10 µM (c) of MRT67307, TPCA, or both inhibitors for 24–72 h. Cell viability was measured using the CellTiter-Glo assay for ATP levels. The viability of cells treated with DMSO was set at 100% for each time point. The results represent the mean ± S.D. from three independent experiments. *p < 0.05; **p < 0.01.

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