Fig. 8: NR1D1 activation alleviates cartilage destruction by inhibiting expression of MMPs and proinflammatory cytokines in vivo.
From: NR1D1 modulates synovial inflammation and bone destruction in rheumatoid arthritis
a, b Safranin-O and toluidine blue staining and c clinical scores of ankle-joint and knee-joint specimens. Data are means ± SEM (n = 8–10 mice per group). *p < 0.05, **p < 0.01 versus the vehicle group. d Immunohistochemical staining of MMP3, MMP13, IL-1β, iNOS, and COX2 in joint synovial tissues (original magnification 10×, scale bar = 100 μm). e Images of TRAP-stained ankle sections (top) and number of TRAP-positive cells (bottom). Data are means ± SEM (n = 8–10 mice per group). *p < 0.05, **p < 0.01 versus the vehicle group. f Schematic representation of NR1D1 regulates synovial inflammation and bone destruction in rheumatoid arthritis. Activation of NR1D1 reduced the expression of proinflammatory cytokines and MMPs in RA FLSs and macrophage activation and alleviated cartilage and bone destruction in rheumatoid arthritis.
