Fig. 6: Hyper-5hmC resulted from UHRF1 deletion.
From: UHRF1-repressed 5’-hydroxymethylcytosine is essential for the male meiotic prophase I
a Venn diagram depicting reduced transcripts associated with 5hmC downregulation. b 5hmC level of meiosis prophase I spermatocytes (16 dpp). c 5hmC densities of all chromosomes. d The distribution of 5hmC density on the genome of spermatocytes. e Venn diagram depicting 5hmC peaks in Uhrf1f/f;Stra8-cre and Uhrf1f/f spermatocytes. f 5hmC densities was shown in the proximal promoter, TSS, and gene body regions of the DEGs. g 5hmC densities in TSSs of the total refgenes with different RPKMs. h The percentage of RNA polymerase II staining in pachynema. i Double immunofluorescence of testicular spread preparations, SYCP3 (red) and RNA polymerase II (green). Scale bar, 5 μm in i.
