Fig. 1: SET7/9 is upregulated in breast cancer tissues and predicts a worse prognosis. | Cell Death & Disease

Fig. 1: SET7/9 is upregulated in breast cancer tissues and predicts a worse prognosis.

From: SET7/9 promotes multiple malignant processes in breast cancer development via RUNX2 activation and is negatively regulated by TRIM21

Fig. 1: SET7/9 is upregulated in breast cancer tissues and predicts a worse prognosis.

a The expression of SET7/9 was determined in breast cancer specimens and normal breast tissues. The images were taken from the online database of the Human Protein Atlas. b The relative expression of SET7/9 was measured in different breast cancer cohorts, including GSE9893 and GSE12276. c The overall survival times and local relapse times in the large cohort of breast cancer patients were analyzed by Kaplan–Meier analysis using the GSE9893 and GSE12276 data sets, and the log-rank p value is shown. d Kaplan–Meier plots show the association between SET7/9 mRNA expression and patient overall survival times in patients with breast cancer, cervical cancer, lung adenocarcinoma, bladder cancer, stomach cancer, and thymoma. e RT-qPCR and western blot analysis were used to measure the expression of SET7/9 in normal breast epithelial cells and breast cancer cells including T-47D, MCF-7, UACC-812, MDA-MB-231, and MDA-MB-468. Values are mean ± S.D. n = 3. *P < 0.05, **P < 0.01.

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