Fig. 5: Id3−/− BMMSCs suppress SS more efficiently than WT BMMSCs. | Cell Death & Disease

Fig. 5: Id3−/− BMMSCs suppress SS more efficiently than WT BMMSCs.

From: Depletion of ID3 enhances mesenchymal stem cells therapy by targeting BMP4 in Sjögren’s syndrome

Fig. 5: Id3−/− BMMSCs suppress SS more efficiently than WT BMMSCs.

a Salivary flow rates in Id3−/− BMMSC- (with/without previous BMP4 or COX2 inhibition) and WT BMMSC-treated NOD/ShiLtJ mice. b, c H&E staining of inflammatory cell infiltration in submandibular glands and effects of BMP4 inhibition; scale bars: 200 μm. d, e Number of CD4+ T cells and Th1 cells in submandibular glands (n = 10, three independent experiments). Values are means ± SD. Student’s t tests and one-way ANOVA. *P ≤ 0.05; **P ≤ 0.01.

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