Fig. 7: Ectopic SBDS suppresses cancer cell growth in vitro.
From: Dual regulation of p53 by the ribosome maturation factor SBDS
a, b SBDS promotes apoptosis more dramatically in HCT116p53+/+ cells than that in HCT116p53−/− cells. Cells were transfected with control or SBDS plasmid followed by the Annexin V-FITC and flow cytometry analysis. Quantification of the apoptotic cells are shown in b. c, d SBDS more dramatically suppresses colony-forming ability of HCT116p53+/+ cells than that of HCT116p53−/− cells. Cells were transfected with control or SBDS plasmid followed by the colony formation assay. e, f SBDS inhibits proliferation of HCT116p53+/+ e and H460 cells f. Cells were transfected with control or SBDS plasmid followed by the cell viability assay.
