Fig. 3: Overexpression of CircHIPK3 or LncGAS5 promotes Th2 differentiation of OVA-induced CD4+ T cells. | Cell Death & Disease

Fig. 3: Overexpression of CircHIPK3 or LncGAS5 promotes Th2 differentiation of OVA-induced CD4+ T cells.

From: The regulatory network among CircHIPK3, LncGAS5, and miR-495 promotes Th2 differentiation in allergic rhinitis

Fig. 3

CD4+ T cells, isolated from PBMCs of AR patients or spleen tissues of mice, were induced by OVA and Th2 inducing agents for 7 days after the transfection of CircHIPK3 lentivirus (lenti-CircHIPK3) or LncGAS5 lentivirus (lenti-LncGAS5). a, b The percentage of Th2 cells, the protein level of GATA-3, and the supernatant level of IL-4 were detected using flow cytometry, western blot analysis, and ELISA, respectively. **p < 0.01 vs OVA + lenti-GFP.

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