Fig. 6: The effects of miR-107 on PTC cell proliferation and invasion. | Cell Death & Disease

Fig. 6: The effects of miR-107 on PTC cell proliferation and invasion.

From: RETRACTED ARTICLE: The HOTAIRM1/miR-107/TDG axis regulates papillary thyroid cancer cell proliferation and invasion

Fig. 6

a The expression levels of miR-107 in PTC cell lines and normal thyroid follicular epithelial cells (n = 3, **p < 0.001). b The expression levels of miR-107 were determined in miR-107-knockdown B-CPAP and TPC-1 cells by qRT-PCR (n = 3, **p < 0.001). c, d Cell proliferation was evaluated by CCK-8 (n = 3, **p < 0.001) (c) and colony-formation assays (n = 3, **p < 0.001) (d) in B-CPAP and TPC-1 cells transfected with anti-miR-107. e Apoptosis was analyzed by flow cytometry (n = 3, **p < 0.001). f, g Knockdown of miR-107 inhibited the invasion of B-CPAP (f) and TPC-1 (g) cells, as determined by transwell assays (n = 3, **p < 0.001). Scale bar: 100 μm. h Tumor growth curve of xenograft tumors formed from B-CPAP cells transfected with anti-NC or anti-miR-107 (n = 5, **p < 0.001). i Photographs of xenograft tumors. j Weight of xenograft tumors (n = 5, **p < 0.001). k The expression levels of miR-107 in xenograft tumor tissues assessed by qRT-PCR (n = 5, **p < 0.001). l Representative photographs of immunohistochemical staining of Ki-67 in xenograft tumors. Scale bar: 50 μm.

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