Fig. 8: miR-590 decreases tumour growth and metastasis by VEGFR1/2 and NRP1 in nude mice. | Cell Death & Disease

Fig. 8: miR-590 decreases tumour growth and metastasis by VEGFR1/2 and NRP1 in nude mice.

From: The regulatory mechanism and biological significance of the Snail-miR590-VEGFR-NRP1 axis in the angiogenesis, growth and metastasis of gastric cancer

Fig. 8

a miR-590 expression in tumour xenografts was measured using qRT-PCR after transfection with miR590 or cont-miR. b Left panel: Primary tumour growth from nude mice with forced expression of miR-590 or cont-miR, with or without VEGFR1/2 and NRP1 restoration. Right panel: Representative image of xenograft tumours are shown. c VEGFR1/2 or NRP1 expression in tumour xenografts was detected by immunohistochemical staining. d D-MVD in tumour xenografts was detected by immunohistochemical staining with the forced expression of miR-590 or cont-miR, with or without VEGFR1/2 and NRP1 restoration. e Representative IVIS images of lung metastases in nude mice that received a tail vein injection of miR-590 or cont-miR with or without VEGFR1/2 or NRP1-infected AGS cells are shown. f The average numbers of lung micrometastases in nude mice. The data are shown separately in nude mice; *p < 0.05. g Schematic representation of Snail-miR590-VEGFR-NRP1 axis. Green arrow means activation, and red arrow means inhibition.

Back to article page