Fig. 1: TLR4 expression and STAT3 phosphorylation positively correlate in human melanoma samples.
From: Activation of STAT3 is a key event in TLR4 signaling-mediated melanoma progression
a Immunohistochemical (IHC) staining of the expression of TLR4 and phosphorylated STAT3 (p-STAT3; Tyr705) in a human melanoma tissue microarray. Scale bar: 5 mm. b Quantification of TLR4 and p-STAT3 staining intensity in the melanoma tissue microarray. *p < 0.05, **p < 0.01. c IHC staining of TLR4 and p-STAT3 in representative melanoma specimens and normal skin tissues. Scale bar: black, 200 μm; red, 50 μm. d Scatter plots of TLR4 and p-STAT3 immunostaining intensity in human melanoma tissues (n = 208). e Scatter plots of TLR4 and p-STAT3 immunostaining intensity in early-stage melanoma tissues (n = 7).
