Fig. 1: TG2 deficiency attenuates IMQ-induced psoriasis-like dermatitis. | Cell Death & Disease

Fig. 1: TG2 deficiency attenuates IMQ-induced psoriasis-like dermatitis.

From: Keratinocyte transglutaminase 2 promotes CCR6+ γδT-cell recruitment by upregulating CCL20 in psoriatic inflammation

Fig. 1

The right ear and shaved back skin of wild-type (WT) and TG2−/− mice were treated with Aldara cream daily for 6 days, and skin inflammation was evaluated. a Phenotypic representation of psoriasiform lesions in WT and TG2−/− mice on day 4. b Ear-skin thickness of WT and TG2−/− mice measured daily for 10 days (n = 8/group). c Back skin erythema, thickness, scaling, and cumulative score assessed daily (scale: 1–10) (n = 8/group). d, e Ear (d) and back skin (e) H&E staining for WT and TG2−/− mice. f BrdU incorporation was detected by immunohistochemistry (left). Bars (right) represent the mean number of BrdU-positive cells (n = 8/group). Data represent the mean ± SEM. *p < 0.05; **p < 0.01 vs. WT mice.

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