Fig. 6: Human psoriatic skin exhibits a high correlation between TG2 and psoriatic cytokine and chemokine expression. | Cell Death & Disease

Fig. 6: Human psoriatic skin exhibits a high correlation between TG2 and psoriatic cytokine and chemokine expression.

From: Keratinocyte transglutaminase 2 promotes CCR6+ γδT-cell recruitment by upregulating CCL20 in psoriatic inflammation

Fig. 6

a–d Gene-expression profile and TG2 correlation were analyzed using reported microarray data from 64 normal controls (NN) and normal skin lesions (PN) and psoriatic lesions (PP) from 58 psoriatic patients. a TG2 mRNA levels in NN, PN, and PP groups. *p < 0.05; **p < 0.01; ***p < 0.001. b Correlation between TG2 levels and 23,520 genes was analyzed by Spearman’s rank correlation. The ranking and correlation coefficient of the indicated genes are presented in the plots. Scatter plots of correlation between TG2 expression and IL6, CXCL8, and CCL20 expression (c) and IL17F, IL17A, and IL22 expression (d) in NN, PN, and PP groups.

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