Fig. 4: Dynamic changes in genomic AcH3 binding during trophoblast differentiation. | Cell Death & Disease

Fig. 4: Dynamic changes in genomic AcH3 binding during trophoblast differentiation.

From: Histone deacetylase 1 and 2 drive differentiation and fusion of progenitor cells in human placental trophoblasts

Fig. 4

a Pie chart showing total number of AcH3 peaks, and the number of peaks that increased or decreased AcH3 binding during syncytiotrophoblast development by at least twofold (Padj < 0.01). b Top 10 chromosomal regions exhibiting decreased (black bars) and increased (blue bars) AcH3 binding during differentiation. Genes located proximate (<1 kb) to these chromosomal areas are included above each bar. c Representative genome browser views of chromosomal regions proximate to LHX4, (ΔN)TP63, TEAD4, CGB, OVOL1, and SYDE1, which exhibit differential AcH3 binding in undifferentiated and differentiation conditions. d Immunohistochemistry for TEAD4 and CGB on first trimester human placental sections. Arrowheads denote syncytiotrophoblast; arrows point to cytotrophoblasts. Scale bars represent 50 μm.

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