Fig. 3: Formate incresses AICAR and suppresses the AMPK activity.
From: Formate induces a metabolic switch in nucleotide and energy metabolism
a–h Metabolic changes associated with increasing the availability of one-carbon units. Only metabolites relevant for the discussion are reported. The full list of metabolites analysed can be found in Table S4. i Immunoblots of AMPK, phospho-AMPK, ACC and phospho-ACC (one representative experiment from three). j, k Quantification of immunoblots at the 24-h time point. Notations: +F denote 1 mM formate supplementation. Symbols represent independent experiments. Error bars represent the standard deviation. Solid bars indicate significant change (p < 0.05) and dashed bars trend (p < 0.1) relative to untreated cells of the same genetic background (two-sided, unequal variance, T test).
