Fig. 2: Irradiated MSCs promote lung metastasis of 4T1 cells. | Cell Death & Disease

Fig. 2: Irradiated MSCs promote lung metastasis of 4T1 cells.

From: Irradiation induces cancer lung metastasis through activation of the cGAS–STING–CCL5 pathway in mesenchymal stromal cells

Fig. 2

a MSCs and irradiated MSCs (12 Gy) were analyzed by the surface markers using flow cytometry. b 4T1 cells and MSCs were irradiated (12 Gy) and cultured for 24 h before the apoptosis ratios were analyzed by flow cytometry. c, d Schematic diagram of experimental protocol (c). MSCs were cultured for 24 h after irradiation (6 Gy or 12 Gy), and then were co-injected with 4T1 cells (5 ×104) into BALB/c mice via tail vein. Metastasis lung tumor nodules were counted after 14 days (d). n ≥ 4 for each group. All experiments in this figure were repeated at least three times. **p < 0.01, ***p < 0.001; ns not significant.

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