Fig. 1: Dose-dependent effects of taxanes on mitosis execution.
Top panels; normal chromosome segregation (untreated cells). Middle panels; at high doses (high taxanes), taxanes activate the SAC and delay mitosis exit. This translates in activation of apoptotic pathways that lead to cell death. Nevertheless, cancer cells can escape cell death induced by high taxanes and slip through mitosis without dividing but forming micronuclei (see main text). Lower panels; at low doses (low taxanes), taxanes do not induce significant delay in mitosis exit but rather induce chromosome segregation errors (mitosis exit with chromosome missegregation) and the formation of micronuclei in daughter cells.
