Fig. 4: STAT5A transcriptionally induced SNHG17 and SNORA71B. | Cell Death & Disease

Fig. 4: STAT5A transcriptionally induced SNHG17 and SNORA71B.

From: LncRNA SNHG17 aggravated prostate cancer progression through regulating its homolog SNORA71B via a positive feedback loop

Fig. 4: STAT5A transcriptionally induced SNHG17 and SNORA71B.

a Venn pattern showed 22 TFs for SNHG17 and SNORA71B promoter predicted by JASPAR, UCSC, and PROMO. b Pulldown assay showed the interaction of STAT5A with SNHG17 and SNORA71B promoter. c RT-qPCR analysis confirmed the knockdown efficiency of STAT5A in PC cells. d RT-qPCR expression of SNHG17 and SNORA71B in PC cells under SNHG17 silence. e 5 STAT5A sites on SNHG17 and SNORA71B promoter were predicted by JASPAR. f ChIP assay showed that STAT5A bound to site 1, 2, and 4 of SNHG17 and SNORA71B promoter. g Luciferase reporter assay was used to evaluate the effect of STAT5A on transcription of SNHG17 and SNORA71B promoter. h Pearson’s correlation curve showed the positive correlation of STAT5A with SNORA71B and SNHG17 in PC samples. *P < 0.05, **P < 0.01.

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