Fig. 7: A schematic model for SMAD4 protects FZD4.
From: SMAD4 activates Wnt signaling pathway to inhibit granulosa cell apoptosis
The schematic diagram depicting the mechanism that SMAD4 protects FZD4 expression and functions: (i) binds to the promoter of FZD4 and initiates FZD4 transcription directly; (ii) functions as a transcription factor for a pig novel lncRNA, SDNOR which further sponges miR-29c and relieves its suppression to FZD4.
