Fig. 1: HK2 is highly expressed in oral squamous cell carcinoma (OSCC) cells. | Cell Death & Disease

Fig. 1: HK2 is highly expressed in oral squamous cell carcinoma (OSCC) cells.

From: Tanshinone IIA inhibits oral squamous cell carcinoma via reducing Akt-c-Myc signaling-mediated aerobic glycolysis

Fig. 1: HK2 is highly expressed in oral squamous cell carcinoma (OSCC) cells.

a–c Normalized 2-DG uptake (a), lactate production (b), and O2 consumption (c) in a panel of OSCC cells (SCC15, SCC9, CAL27, and SCC25) and normal oral epithelial cells under normoxic conditions. d Immunoblotting (IB) analysis of HK2 expression in OSCC and hTERT-OME cells. e The representative IB results of HK2 expression in 30 cases of matched OSCC patient tissues and adjacent tissues. T tumor, N adjacent non-tumor tissue. f Colony formation of CAL27 and SCC15 cells expressing sgCtrl or sgHK2. Scale bar, 50 µm. g Cell viability of CAL27 and SCC15 cells expressing sgCtrl or sgHK2. Top, IB analysis of HK2 expression. Bottom, MTS analysis of cell viability. h–j In vivo tumor growth of CAL27 cells expressing of sgCtrl or sgHK2. h tumor volume. i The image of the tumor mass. Scale bar, 1 cm. j The weight of the tumor mass. *p < 0.05, **p < 0.01, ***p < 0.001.

Back to article page