Fig. 6: HDAC1 silencing reduces cell death and neurodegeneration induced by hTDP-43 expression in Drosophila eye.
From: HDAC1 inhibition ameliorates TDP-43-induced cell death in vitro and in vivo
Eyes of flies expressing different transgenes under control of GMR-Gal4, are shown (a). TDP-43 on its own induces strong eye degeneration and the appearance of dark spots (BBS big black spots), which are an indication of massive cell death. RNAi-mediated downregulation of dHDAC1 significantly improves TDP-43-mediated neurodegeneration and cell death, as indicted by the reduction of dark areas of degeneration. b Graphic representation of the data (a), in which we counted the number of eyes showing cell death areas (BBS) in fly expressing TDP-43 on its own, or together with dHDAC1 RNAi construct, and we compared their frequencies. Statistical significance was tested by CHI-square (Yates correction).
