Fig. 8: Graphical presentation of LL22NC03-N14H11.1/c-Myb/LTZR1/H-RAS/MAPK/DRP1 axis in HCC. | Cell Death & Disease

Fig. 8: Graphical presentation of LL22NC03-N14H11.1/c-Myb/LTZR1/H-RAS/MAPK/DRP1 axis in HCC.

From: LncRNA LL22NC03-N14H11.1 promoted hepatocellular carcinoma progression through activating MAPK pathway to induce mitochondrial fission

Fig. 8: Graphical presentation of LL22NC03-N14H11.1/c-Myb/LTZR1/H-RAS/MAPK/DRP1 axis in HCC.The alternative text for this image may have been generated using AI.

LL22NC03-N14H11.1 interacted with c-Myb to transcriptionally repress LZTR1, so as to decrease H-RAS (G12V) ubiquitination, activate MAPK pathway, and induce p-DRP1 (S616), resulting in induced mitochondrial fission and accelerated HCC progression.

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