Fig. 2: Lycorine elevates the tumor suppressor SAV1 levels and reduces the oncogenic YAP amounts in the tumors from xenograft mice. | Cell Death & Disease

Fig. 2: Lycorine elevates the tumor suppressor SAV1 levels and reduces the oncogenic YAP amounts in the tumors from xenograft mice.

From: Correction of the tumor suppressor Salvador homolog-1 deficiency in tumors by lycorine as a new strategy in lung cancer therapy

Fig. 2

The levels of SAV1 and YAP proteins in the tumors from xenograft mice were detected by IHC and IF, respectively. Lycorine raised SAV1 levels (IHC: a, b, ×200; IF: c, ×1000), while YAP amounts were decreased by lycorine treatment (IHC: d, e). The amounts of SAV1, YAP, and β-actin in the tumor tissues from xenograft mice were detected by western blotting (f–h) and RT-PCR (i), respectively. LH + represents with lycorine treatment, LH− represents vehicle control. Data represent the mean ± SD of triplicates. *P < 0.05. **P < 0.01. ***P < 0.001.

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