Table 1 A summary of FOXF2 expression, mechanism, function in tumours.
From: FOXF2 acts as a crucial molecule in tumours and embryonic development
Tumour | Expression | Mechanism | Function | Reference |
|---|---|---|---|---|
Breast cancer (in mice) | – | TGF-β/↑FOXF2/↓E-cadherin, ↑Zeb1, ↑Zeb2, ↑Noxa, ↓Id2, ↓miR-200 family, ↓betacellulin, ↓amphiregulin/↑EMT | Promoting apoptosis, migration | |
Breast cancer | –(BLBC) | 1. MAZ/↑FOXF2/↓Twist1/EMT↓ 2. MAZ/↑FOXF2/- | 1. Inhibiting migration 2. Promoting proliferation | |
Breast cancer | Upregulation | ↑FOXF2/↑BMP/ SMAD pathway, ↑BRGs | Promoting bone metastasis | |
Breast cancer | Upregulation | ↓miR-200c/↑FOXF2/↓E-cadherin, ↑Zeb1/↑EMT | Promoting invasion, migration, metastasis | |
Breast Cancer | Upregulation in BLBC | ↑FOXF2/↑EMT | Promoting invasion, migration | |
Breast cancer | Downregulation | ↑miR-301/↓ FOXF2/↑Wnt5a | Inhibiting proliferation, migration | |
Breast cancer | Downregulation in BLBC | ↓FOXF2/↑Twist1/↑ EMT | Inhibiting metastasis | |
Breast cancer | Downregulation in BLBC | ↓FOXF2/↑FOXC2/↑EMT | Inhibiting proliferation, invasion, metastasis | |
Breast cancer | Downregulation in BLBC | ↓SP1/↓FOXF2 | Inhibiting proliferation | |
Breast cancer | Downregulation in BLBC | ↓FOXF2/↑VEGFR3 | Inhibiting lymphatic metastasis | |
Breast cancer | Downregulation in luminal-type and HER2-positive breast cancer | ↓FOXF2/↑CDK2-RB-E2F cascade | Inhibiting proliferation | |
Lung cancer | Downregulation in NSCLC | – | Inhibiting cancer progression | |
Lung cancer | Upregulation | ↑FOXF2/↓E-cadherin, ↓miR-200/↑EMT | Promoting, invasion, migration, metastasis | |
CRC | Downregulation | ↑miR-130a, ↑miR-182/↓FOXF2/↑β-catenin | Inhibiting proliferation, invasion, migration | |
CRC | Downregulation | ↑LSD1/↓FOXF2/↑EMT | Inhibiting proliferation, invasion, migration | |
HCC | Downregulation | ↑miR-519a/↓FOXF2/↑E-Cadherin, ↓ vimentin/↓EMT | Inhibiting proliferation, colonization, metastasis, promoting invasion, migration | |
PC | Downregulation | ↑miR-182-5p/↓FOXF2/↑MMP1, ↓TIMP3/↓ECM | Inhibiting proliferation, invasion, migration | |
ESCC | Downregulation | DNA promoter methylation/↓FOXF2 | Inhibiting cancer progression | |
Cervical cancer | Downregulation | ↓FOXF2/↑β-catenin/↑EMT | Inhibiting proliferation, invasion, migration | |
OC | downregulation | ↓ADAMTS9-AS2/↑miR-182-5p/↓FOXF2/↑EMT | inhibiting proliferation, invasion, migration | |
GC | Downregulation | DNA promoter methylation/↓FOXF2/↓E3 ligase IRF2BPL /↑Wnt/β-catenin pathway | Inhibiting proliferation, invasion, migration | |
Intestinal Adenomas (in mice) | Downregulation | ↓FOXF2/↓SFRP1/↑Wnt | Inhibiting formation and growth | |
RMS (in mice) | Upregulation | ↑FOXF2/↓p21 | Promoting proliferation |
