Table 2 A summary of the aberrant expression of FOXF2 and the mechanism of related disease.
From: FOXF2 acts as a crucial molecule in tumours and embryonic development
Expression location | Organ | Species | Related disease | Mechanism | Reference | |
|---|---|---|---|---|---|---|
Head | Face | Cochlea | Human | Sensorineural hearing loss | ↓FOXF2 | |
Head | Face | Cochlea | Mouse | Inner ear anomalies | ↓Foxf2/↓Eya1, ↓Pax3 | |
Head | Face | Lip | Mouse | Cleft lip | ↓Hh signalling/↓Foxf2 | |
Head | Face | Tongue | Mouse | Aglossia | Cilia mutation/↓GLIA/↓Foxf2 | |
Head | Face | Eye | Human | Persistent hyperplastic primary vitreous | ↑FOXF2 | |
Head | Face | Eye | Human | Corectopia and dysplasia of anterior chamber of eyes | ↓FOXF2 | |
Head | Face | Tooth | Human | Teeth dysplasia | ↓FOXF2 | |
Head | Face | Palate | Mouse | Cleft palate | ↓Foxf2/↓Tgfbr3, ↓integrins αV, ↓integrinsβ1/↓TGF-β signal | |
Head | Cranium | Brain | Mouse | Intracranial haemorrhage | ↓Foxf2/↓TGF-β signal/↓Gpr124 mRNA | |
Digestive and respiratory systems | – | GI tract | Mouse | Excessive growth of intestinal epithelium | ↓Foxf2/↑Wnt5a, ↓Bmp4 | |
Digestive and respiratory systems | – | Lung | Human | Broncho-pulmonary dysplasia | ↓FOXF2 | |
Mesoderm-derived organs | – | Diaphragm | Human | Congenital diaphragmatic hernia | ↓FOXF2 | |
Mesoderm-derived organs | – | Cartilage | Zebrafish | Midline cartilage defects | ↓foxf2/↓col2a1, ↓acan | |
Mesoderm-derived organs | – | Heart | Mouse | Atrioventricular septal defect | ↓Foxf2 | |
