Fig. 1: FOXM1 promoted cell proliferation, migration, EMT as well as tumor growth and metastasis in LUAD. | Cell Death & Disease

Fig. 1: FOXM1 promoted cell proliferation, migration, EMT as well as tumor growth and metastasis in LUAD.

From: Circ-MMP2 (circ-0039411) induced by FOXM1 promotes the proliferation and migration of lung adenocarcinoma cells in vitro and in vivo

Fig. 1: FOXM1 promoted cell proliferation, migration, EMT as well as tumor growth and metastasis in LUAD.The alternative text for this image may have been generated using AI.

a FOXM1 level in LUAD samples versus normal ones were obtained from TCGA. b qRT-PCR results of FOXM1 level in LUAD cells versus normal ones. c Pictures of EdU-stained cells (scale bar = 100 μm) was taken and ratio of EdU-stain ratio was evaluated. d Images of colonies and quantification of colony formation efficiency in LUAD cells under FOXM1 knockdown. e Migrated cells in transwell chamber were pictured and counted under FOXM1 knockdown (scale bar = 100 μm). f Western blot was adopted to detect EMT-related markers. GAPDH was an internal control. g, h Tumor volume and weight was tested after silencing FOXM1. i IHC was utilized to test cell proliferation and EMT markers after silencing FOXM1 (scale bar = 50 μm). j Number of metastatic nodules was detected by H&E staining (scale bar = 50 μm). k Western blots of EMT-related proteins in xenografts with FOXM1 knockdown. *P < 0.05, **P < 0.01.

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