Fig. 4: Expression of HOXA5 in cervical cancer cells impeded cell cycle transition from G0/G1 to S phase. | Cell Death & Disease

Fig. 4: Expression of HOXA5 in cervical cancer cells impeded cell cycle transition from G0/G1 to S phase.

From: HOXA5 inhibits the proliferation and neoplasia of cervical cancer cells via downregulating the activity of the Wnt/β-catenin pathway and transactivating TP53

Fig. 4

a In the flow cytometry figures, the y-axis shows the count of effective cells and the x-axis shows the DNA content. Each colored area represents the cells of different phases of cell cycle: green area refers to the cells in the G0/G1 phase, yellow area refers to the cells in the S phase, and blue area refers to the cells in the G2/M phase. The cell cycles of HeLa-GFP and HeLa-HOXA5 cells were analyzed using flow cytometry (a), and a quantitative analysis of the cell cycle are shown (b). The cell cycles of SiHa-GFP and SiHa-HOXA5 cells (c) and the quantitative analysis (d) are shown. The cell cycles of C-33A-shCtrl and C-33A-shHOXA5 cells (e) and the quantitative analysis (f) are shown. The cell cycles of C-33A-criCtrl and C-33A-cri HOXA5 cells (g) and the quantitative analysis (h) are shown. The data were shown as the mean ± SD of three independent experiments. Data were statistically analyzed with Student’s t-test and values are shown as mean ± SD. *p < 0.05, **p < 0.01, ***p < 0.001.

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